quantitative Single-Molecule Localization Microscopy is the core of our work.

Digitized Experimental Microscopy

Jun.Prof. Dr. Christian Franke
quantitative Single-Molecule Localization Microscopy is the core of our work.
Image: Christian Franke

News

Twitter

  • 2022/12/01: Our work on Lipid Nanopraticles for mRNA delivery started in Dresden @MPICBG is featured in The Year in Cell Biology: 2022 of the Journal of Cell Biology. We are building on this work with our project in the CRC Polytarget analysing the nanoscale cellular distributing of polymeric nanoparticles and their cargo. Our fantastic student Lukas Harder is pushing this together with polytarget partners.
  • 2022/11/04: Our manuscript with the Holthoff Lab @UKJ is now online at @biorxiv. Andreas managed to tune his #structuredillumination based #stereophotogrammetry system to record mice whiskers with 3D micrometer resolution for the first time. This wat, we could contribute to understand the ovelap between the visual and tactile field of view in mice. Fantastic paper and much more to come from Andreas in this direction. Congratulations!
  • 2022/10/15: Kristina and Matthew are joining us for their Research Labworks and Master Thesis'. Kristina will work with Andreas and the Holthoff Lab @UKJ to further optimize our new structured illumination based 3D reconstruction approach of mice whisker. Matthew is working on rel time computation of large 3D point cloud data sets, both for microscopy and 3D measurements. Welcome and have Fun!
  • 2022/08/25: Gregor has been selected for this years EMBO Practical Course Computational Optical Biology in Oeiras, Portugal and awarded a Travel Grant from EMBO! Congratulations and have fun!
  • 2022/08/17: Steev successfully defended his Master Thesis on smart glasses with Tooz Technologies and will continue working with them as a full time employee. Congratulations and all the best!
  • 2022/07/18: Andreas' paper on "Miniaturization of a coherent monocular structured illumination system for future combination with digital holography" is now published in Light: Advanced Manufacturing. Congratulations! Much more to come soon. paper
News Archiv Expand entry
  • 2022/07/01: Aninidita from @AgEggeling and our very own Dr. Andreas Stark where awarded for their outstanding PhD works. Anindita got the Zeiss 'Ph.D. Award in Modern Optics' and Andreas the 'Ph.D. Award of Dr.-Ing. Siegfried Werth Foundation'. Congratulations! #IAOBpower
    • Anindita works at #IAOB and @Leibniz_IPHT as a PhD student on the development of multi-modal #SuperresolutionMicroscopy methods and Andreas is a postdoc with us and works on multi-scale optical measurements by structured illumination. Many great things to come from these two!
  • 2022/06/01: Nabil joins the group and will work on augmented reality glasses for his Master Thesis with OQmented. Welcome!
  • 2022/04/15: Liju joins us as for his Research Lab work on Pattern Optimization for Structured Illumination. Welcome! 
  • 2022/04/15: Kedar joins us as for his Research Lab work on 360 degree reconstruction. Welcome! 
  • 2022/04/07: Friedrich joins us as for his Bachelor Thesis on super-fast Pattern Creation for Structured Illumination. Welcome! 
  • 2022/04/01: Andrey joins us as a Research Assistant and will work on Computer Vision and Machine Learning for Super-Resolution Microscopy. Welcome! 
  • 2022/04/01: Lukas joins us as a Research Assistant and for his Bachelor Thesis on super-high resolution imaging of endosomal compartments. Welcome! 
  • 2022/03/18: Our recent paper on mRNA escape from endosomal recycling tubules, analysed by multi-colour dSTORM in the Journal of Cell Biology is featured in this weeks issue of Science! Wow! #mindblown
  • 2022/03/15: Andreas' paper on "Miniaturization of a coherent monocular structured illumination system for future combination with digital holography" has been accepted in Light: Advanced Manufacturing. Congratulations! Much more to come soon.
  • 2022/03/09: Our straight-forward & accessible-for-all workflow to quantitatively map and analyse the 3D-distribution of (T-) cell surface receptors with #isotropic nanometer resolution, while preserving the native membrane topography is now published in Communications Biology
  • 2021/11/01: Andreas joins the group as a postdoctoral Researcher after successfully finishing his PhD with Prof. Kowarschik. Andreas is an expert in macroscopic 3D measurement based on structured illumination and will broaden the scope of the group. Fun things to come I am sure! Welcome!
  • 2020/11/01: Gregor gives the new Franke Lab a kick start in joing me right away. Gregor is starting his PhD thesis #FirstPhDStudent. Welcome and have fun - let's do this!
  • 2020/11/01: First Day in the Office @FSU - #Exciting #NewPI

 

The basic principle of Single-Molecule Localisation Microscopy
Image: Christian Franke
Research & Projects
What are we doing?
Go Team
Image: Christian Franke
Team
Go Team! #TeamRedbeard
Fiberoptics
Image: Jan-Peter Kasper (University of Jena)
Publications
Latest #preprints and manuscripts from the Lab.
Old Microscopy Patents
Image: Christian Franke
Teaching
Learning by Doing & Teaching.
Take the Red Pill.
Image: Christian Franke
Software
Take the Red Pill.
Fun from the Lab and beyond.
Image: Christian Franke
Galery
Fun from the Lab and Beyond.
Single-Molecule Blinking of Fluorescent Dyes
 Video: Christian Franke

Single-Molecule Blinking of Fluorescent Dyes - Every spot represents a nanometer size dye molecule, imaged in a wide-field microscope onto a EMCCD chip. Detecting single molecules allows us to create super-resolution fluorescence images way beyond the Abbe diffraction limit.

Institute of Applied Optics and Biophysics - Group Experimental Digitized Microscopy
Helmholtzweg 4
07743 Jena
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+49 03641 9-47112
christian.franke@uni-jena.de
Postal address:
Friedrich-Schiller-Universität Jena
Institut für Angewandte Optik und Biophysik
Max-Wien-Platz 1
07743 Jena